Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 620283..621082 Replicon chromosome
Accession NZ_CP117556
Organism Escherichia albertii strain BIA_89-5

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag PS032_RS03160 Protein ID WP_000347251.1
Coordinates 620283..620747 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag PS032_RS03165 Protein ID WP_001296435.1
Coordinates 620747..621082 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS032_RS03130 (615284) 615284..615718 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PS032_RS03135 (615736) 615736..616614 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PS032_RS03140 (616604) 616604..617383 - 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
PS032_RS03145 (617394) 617394..617867 - 474 WP_137649678.1 PTS N-acetylgalactosamine transporter subunit IIB -
PS032_RS03150 (617890) 617890..619170 - 1281 WP_059227551.1 tagatose-bisphosphate aldolase subunit KbaZ -
PS032_RS03155 (619419) 619419..620228 + 810 WP_103053960.1 aga operon transcriptional regulator AgaR -
PS032_RS03160 (620283) 620283..620747 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PS032_RS03165 (620747) 620747..621082 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PS032_RS03170 (621231) 621231..622802 - 1572 WP_059218167.1 galactarate dehydratase -
PS032_RS03175 (623173) 623173..624507 + 1335 WP_000599659.1 galactarate/glucarate/glycerate transporter GarP -
PS032_RS03180 (624523) 624523..625293 + 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T271333 WP_000347251.1 NZ_CP117556:c620747-620283 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT271333 WP_001296435.1 NZ_CP117556:c621082-620747 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References