Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 235459..236171 Replicon chromosome
Accession NZ_CP117556
Organism Escherichia albertii strain BIA_89-5

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag PS032_RS01075 Protein ID WP_000162413.1
Coordinates 235869..236171 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PS032_RS01070 Protein ID WP_000806447.1
Coordinates 235459..235797 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS032_RS01045 (230502) 230502..232484 + 1983 WP_000089601.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
PS032_RS01050 (232533) 232533..233561 + 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
PS032_RS01055 (233633) 233633..234163 - 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
PS032_RS01060 (234310) 234310..234876 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
PS032_RS01065 (235223) 235223..235402 - 180 WP_002460167.1 hypothetical protein -
PS032_RS01070 (235459) 235459..235797 - 339 WP_000806447.1 HigA family addiction module antitoxin Antitoxin
PS032_RS01075 (235869) 235869..236171 - 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PS032_RS01080 (236335) 236335..236814 + 480 WP_107193136.1 hypothetical protein -
PS032_RS01085 (236827) 236827..237909 - 1083 WP_265463928.1 IS481 family transposase -
PS032_RS01090 (238005) 238005..238178 - 174 WP_000553433.1 hypothetical protein -
PS032_RS01095 (238206) 238206..238289 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
PS032_RS01100 (238343) 238343..239695 - 1353 WP_000160823.1 glutathione-disulfide reductase -
PS032_RS01105 (239767) 239767..240609 - 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 236827..237909 1082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T271330 WP_000162413.1 NZ_CP117556:c236171-235869 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13010.90 Da        Isoelectric Point: 5.2075

>AT271330 WP_000806447.1 NZ_CP117556:c235797-235459 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNSRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References