Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5920853..5921448 Replicon chromosome
Accession NZ_CP117527
Organism Pseudomonas aeruginosa strain MF1

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PSP57_RS27895 Protein ID WP_003113526.1
Coordinates 5921170..5921448 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag PSP57_RS27890 Protein ID WP_003111575.1
Coordinates 5920853..5921158 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSP57_RS27875 (PSP57_27875) 5917564..5918427 - 864 WP_023098850.1 integrase domain-containing protein -
PSP57_RS27880 (PSP57_27880) 5919028..5920170 - 1143 WP_023098851.1 STY4528 family pathogenicity island replication protein -
PSP57_RS27890 (PSP57_27890) 5920853..5921158 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
PSP57_RS27895 (PSP57_27895) 5921170..5921448 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PSP57_RS27900 (PSP57_27900) 5921501..5921629 - 129 Protein_5516 integrase -
PSP57_RS27905 (PSP57_27905) 5921777..5924005 + 2229 WP_021264080.1 TonB-dependent receptor -
PSP57_RS27910 (PSP57_27910) 5924075..5924722 - 648 WP_003095021.1 carbonate dehydratase -
PSP57_RS27915 (PSP57_27915) 5924784..5926022 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T271320 WP_003113526.1 NZ_CP117527:c5921448-5921170 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT271320 WP_003111575.1 NZ_CP117527:c5921158-5920853 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References