Detailed information of TA system TA027131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 720839..721493
• Replicon: chromosome
• Accession: NC_017621
• Organism: Streptococcus suis D12

Toxin (Protein)

• Gene name: higB
• Uniprot ID: G7SDV0
• Locus tag: SSUD12_RS03660
• Protein ID: WP_014637766.1
• Coordinates: 720839..721204 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: G7SDV1
• Locus tag: SSUD12_RS03665
• Protein ID: WP_014637767.1
• Coordinates: 721194..721493 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSUD12_RS03645	717029..717622	-	594	WP_014637763.1	DUF1361 domain-containing protein	-
SSUD12_RS03650	717778..719781	+	2004	WP_014637764.1	methionine--tRNA ligase	-
SSUD12_RS03655	719842..720795	+	954	WP_014637765.1	competence protein CoiA	-
SSUD12_RS03660	720839..721204	+	366	WP_014637766.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SSUD12_RS03665	721194..721493	+	300	WP_014637767.1	helix-turn-helix transcriptional regulator	Antitoxin
SSUD12_RS03670	721603..723405	+	1803	WP_014637768.1	oligoendopeptidase F	-
SSUD12_RS03675	723407..723850	+	444	WP_014637769.1	hypothetical protein	-
SSUD12_RS03680	723861..724409	+	549	WP_014637770.1	hypothetical protein	-
SSUD12_RS11015	724559..725849	-	1291	Protein_667	IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14435.66 Da
• Isoelectric Point: 10.1354

>T27131 WP_014637766.1 NC_017621:720839-721204 [Streptococcus suis D12]
MYTIYFYKDKNGREPVLEYLRELASKKGKDSRIKLNKINDYIELLSQLGTQIGEPYVKHLEGNIWELRPLRDRILFVAWY
DGSFVLLHHFVKRSQKTPRRELEKAQRELADLKERGINNGK

Nucleotide

• Length: 366 bp

>T27131 NC_017621:720839-721204 [Streptococcus suis D12]
ATGTACACTATTTATTTTTATAAGGATAAAAATGGAAGGGAGCCTGTTTTAGAGTATCTGAGGGAGCTTGCATCTAAAAA
GGGGAAAGATAGCAGGATTAAATTGAATAAGATAAATGATTATATTGAACTTTTAAGTCAACTGGGAACTCAAATTGGTG
AACCATATGTGAAGCACTTGGAAGGTAATATTTGGGAATTGCGTCCCTTAAGAGATAGGATTTTATTTGTCGCATGGTAT
GATGGGAGTTTTGTTTTACTGCATCATTTTGTGAAACGGTCACAGAAAACACCACGGAGGGAGCTTGAAAAGGCTCAACG
TGAGCTGGCAGACTTGAAAGAAAGGGGTATTAACAATGGAAAATAG

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11058.73 Da
• Isoelectric Point: 7.2059

>AT27131 WP_014637767.1 NC_017621:721194-721493 [Streptococcus suis D12]
MENSAIGSNWQSVRSELFSEKEIIESDLRVAIMSELIKARHEQGVSQKRLEELSGVSQPVIARMETGKTSPQLDTILKVL
ASLGKTLAVVPLKQERHFQ

Nucleotide

• Length: 300 bp

>AT27131 NC_017621:721194-721493 [Streptococcus suis D12]
ATGGAAAATAGTGCAATTGGTAGTAACTGGCAATCGGTACGGTCTGAACTCTTCAGTGAGAAGGAAATCATAGAAAGTGA
TTTGCGTGTGGCAATTATGAGCGAACTGATAAAAGCAAGGCATGAACAGGGAGTAAGTCAGAAAAGACTAGAGGAGCTAA
GCGGGGTGAGTCAACCAGTTATTGCAAGAATGGAAACAGGTAAAACTAGTCCACAATTGGACACTATCTTGAAGGTATTG
GCTAGTCTAGGCAAAACTTTAGCAGTTGTGCCTTTGAAACAGGAACGACATTTTCAATAG

Structures

Toxin

• AlphaFold DB: G7SDV0

Antitoxin

• AlphaFold DB: G7SDV1