27129

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2011243..2011762 Replicon chromosome
Accession NC_017620
Organism Streptococcus suis D9

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8M4E9
Locus tag SSUD9_RS09800 Protein ID WP_002939009.1
Coordinates 2011243..2011500 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag SSUD9_RS09805 Protein ID WP_002939010.1
Coordinates 2011502..2011762 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSUD9_RS09785 2007874..2009604 - 1731 WP_024390921.1 membrane protein -
SSUD9_RS09790 2009807..2010715 - 909 WP_074390583.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
SSUD9_RS09795 2010699..2011229 - 531 WP_002939008.1 DUF1697 domain-containing protein -
SSUD9_RS09800 2011243..2011500 - 258 WP_002939009.1 Txe/YoeB family addiction module toxin Toxin
SSUD9_RS09805 2011502..2011762 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SSUD9_RS09810 2011838..2012293 - 456 WP_002939012.1 8-oxo-dGTP diphosphatase -
SSUD9_RS09815 2012297..2012665 - 369 WP_002939013.1 hypothetical protein -
SSUD9_RS09820 2012658..2013248 - 591 WP_002939014.1 ribonuclease M5 -
SSUD9_RS09825 2013211..2013993 - 783 WP_002939015.1 TatD family hydrolase -
SSUD9_RS09830 2014101..2014238 - 138 WP_002939016.1 50S ribosomal protein L34 -
SSUD9_RS09835 2014406..2015401 - 996 WP_013730624.1 protein jag -
SSUD9_RS09840 2015421..2016233 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
SSUD9_RS09845 2016217..2016576 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10321.83 Da        Isoelectric Point: 7.3119

>T27129 WP_002939009.1 NC_017620:c2011500-2011243 [Streptococcus suis D9]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEVDKLYILSL
KDHYG

Download         Length: 258 bp

>T27129 NC_017620:c2011500-2011243 [Streptococcus suis D9]
ATGGGAATCCATTTTACAGAGGATGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTCAAGCGAAT
CAATAAGATTATCAAGGATATGCAACGACATCCTTTTGAAGGCATTGCCAAACCAGAACCCTTGAAGTATGATTATCAGG
GTGCCTGGTCTCGGAGAATTGATGCCGAAAATCGGCTGATTTATATGGTAGAAGTAGATAAGCTGTATATTTTGTCTTTA
AAGGATCATTATGGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT27129 WP_002939010.1 NC_017620:c2011762-2011502 [Streptococcus suis D9]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT27129 NC_017620:c2011762-2011502 [Streptococcus suis D9]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8M4E9

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References