Detailed information of TA system TA271252

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2567590..2568075
• Replicon: chromosome
• Accession: NZ_CP117503
• Organism: Enterococcus faecalis strain CQJXZ21-076

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: PSC77_RS12385
• Protein ID: WP_021164441.1
• Coordinates: 2567590..2567691 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2567866..2568075 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PSC77_RS12360 (2563118)	2563118..2564071	-	954	WP_010709946.1	siderophore ABC transporter substrate-binding protein	-
PSC77_RS12365 (2564110)	2564110..2564865	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
PSC77_RS12370 (2564862)	2564862..2565827	-	966	WP_016622541.1	iron chelate uptake ABC transporter family permease subunit	-
PSC77_RS12375 (2565824)	2565824..2566771	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
PSC77_RS12380 (2566956)	2566956..2567408	+	453	WP_002359057.1	YueI family protein	-
- (2567434)	2567434..2567641	+	208	NuclAT_3	-	-
- (2567471)	2567471..2567645	+	175	NuclAT_6	-	-
PSC77_RS12385 (2567590)	2567590..2567691	-	102	WP_021164441.1	putative holin-like toxin	Toxin
- (2567866)	2567866..2568075	+	210	NuclAT_4	-	Antitoxin
- (2567900)	2567900..2568079	+	180	NuclAT_5	-	-
PSC77_RS12390 (2568024)	2568024..2568125	-	102	WP_075551663.1	putative holin-like toxin	-
PSC77_RS12395 (2568313)	2568313..2570583	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
PSC77_RS12400 (2570754)	2570754..2571254	+	501	WP_010709949.1	cysteine hydrolase family protein	-
PSC77_RS12405 (2571955)	2571955..2572851	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T271252 WP_021164441.1 NZ_CP117503:c2567691-2567590 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT271252 NZ_CP117503:2567866-2568075 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin