Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 504361..504593 Replicon chromosome
Accession NZ_CP117503
Organism Enterococcus faecalis strain CQJXZ21-076

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag PSC77_RS02455 Protein ID WP_002355568.1
Coordinates 504361..504477 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 504388..504593 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC77_RS02445 (499799) 499799..502057 + 2259 WP_002363179.1 DNA helicase PcrA -
PSC77_RS02450 (502183) 502183..504213 + 2031 WP_002364804.1 NAD-dependent DNA ligase LigA -
PSC77_RS02455 (504361) 504361..504477 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (504388) 504388..504593 - 206 NuclAT_2 - Antitoxin
PSC77_RS02460 (504795) 504795..505100 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
PSC77_RS02465 (505100) 505100..506578 + 1479 WP_016622625.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
PSC77_RS02470 (506568) 506568..507998 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
PSC77_RS02475 (508017) 508017..509105 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T271247 WP_002355568.1 NZ_CP117503:504361-504477 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT271247 NZ_CP117503:c504593-504388 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References