Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4654053..4654655 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name higB Uniprot ID A0A5Z1Z935
Locus tag PQQ07_RS22555 Protein ID WP_001159634.1
Coordinates 4654344..4654655 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ07_RS22550 Protein ID WP_000362050.1
Coordinates 4654053..4654343 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS22535 (4651546) 4651546..4652448 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQQ07_RS22540 (4652445) 4652445..4653080 + 636 WP_274896181.1 formate dehydrogenase cytochrome b556 subunit -
PQQ07_RS22545 (4653077) 4653077..4654006 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ07_RS22550 (4654053) 4654053..4654343 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ07_RS22555 (4654344) 4654344..4654655 - 312 WP_001159634.1 hypothetical protein Toxin
PQQ07_RS22560 (4654873) 4654873..4655802 + 930 WP_001127703.1 alpha/beta hydrolase -
PQQ07_RS22565 (4655888) 4655888..4656199 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQQ07_RS22570 (4656196) 4656196..4656642 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ07_RS22575 (4656657) 4656657..4657598 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ07_RS22580 (4657643) 4657643..4658080 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PQQ07_RS22585 (4658077) 4658077..4658949 - 873 WP_000921427.1 virulence factor BrkB family protein -
PQQ07_RS22590 (4658943) 4658943..4659542 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12278.23 Da        Isoelectric Point: 9.4460

>T271209 WP_001159634.1 NZ_CP117404:c4654655-4654344 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVVMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT271209 WP_000362050.1 NZ_CP117404:c4654343-4654053 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z1Z935

Antitoxin

Source ID Structure

References