271208

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4332950..4333731 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag PQQ07_RS21125 Protein ID WP_000626099.1
Coordinates 4332950..4333441 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PQQ07_RS21130 Protein ID WP_001110452.1
Coordinates 4333438..4333731 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS21090 (4328170) 4328170..4328565 + 396 WP_000208386.1 DUF6088 family protein -
PQQ07_RS21095 (4328558) 4328558..4329505 + 948 WP_001440173.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
PQQ07_RS21100 (4329791) 4329791..4329868 - 78 Protein_4123 helix-turn-helix domain-containing protein -
PQQ07_RS21105 (4329959) 4329959..4330291 - 333 WP_001165471.1 MerR family transcriptional regulator -
PQQ07_RS21110 (4330363) 4330363..4330740 + 378 WP_000916345.1 EthD family reductase -
PQQ07_RS21115 (4331773) 4331773..4331847 + 75 Protein_4126 porin family protein -
PQQ07_RS21120 (4331950) 4331950..4332702 + 753 WP_000842434.1 non-specific acid phosphatase -
PQQ07_RS21125 (4332950) 4332950..4333441 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
PQQ07_RS21130 (4333438) 4333438..4333731 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PQQ07_RS21135 (4334048) 4334048..4334269 + 222 WP_001576552.1 hypothetical protein -
PQQ07_RS21140 (4334534) 4334534..4335409 + 876 WP_000921674.1 AraC family transcriptional regulator -
PQQ07_RS21145 (4335406) 4335406..4335693 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ07_RS21150 (4335716) 4335716..4335931 + 216 WP_001595136.1 hypothetical protein -
PQQ07_RS21155 (4335939) 4335939..4336208 + 270 WP_010989096.1 hypothetical protein -
PQQ07_RS21160 (4336417) 4336417..4336875 - 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
PQQ07_RS21165 (4337214) 4337214..4338119 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island floR - 4300626..4336875 36249
flank IS/Tn - - 4336417..4336875 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T271208 WP_000626099.1 NZ_CP117404:c4333441-4332950 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT271208 WP_001110452.1 NZ_CP117404:c4333731-4333438 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References