271200

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2421897..2422419 Replicon chromosome
Accession NZ_CP117404
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM085

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQQ07_RS11800 Protein ID WP_000221343.1
Coordinates 2422135..2422419 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQQ07_RS11795 Protein ID WP_000885424.1
Coordinates 2421897..2422145 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ07_RS11770 (2417113) 2417113..2418579 + 1467 WP_000987828.1 hypothetical protein -
PQQ07_RS11775 (2419387) 2419387..2420101 + 715 Protein_2302 helix-turn-helix domain-containing protein -
PQQ07_RS11780 (2420157) 2420157..2421065 - 909 WP_010989018.1 hypothetical protein -
PQQ07_RS11785 (2421208) 2421208..2421540 - 333 WP_000253154.1 DUF1493 family protein -
PQQ07_RS11790 (2421530) 2421530..2421745 - 216 WP_000206207.1 hypothetical protein -
PQQ07_RS11795 (2421897) 2421897..2422145 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ07_RS11800 (2422135) 2422135..2422419 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ07_RS11805 (2422590) 2422590..2422979 + 390 WP_000194089.1 RidA family protein -
PQQ07_RS11810 (2423031) 2423031..2424110 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQQ07_RS11815 (2424303) 2424303..2424791 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQQ07_RS11820 (2424836) 2424836..2426344 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2417116..2429201 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T271200 WP_000221343.1 NZ_CP117404:2422135-2422419 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT271200 WP_000885424.1 NZ_CP117404:2421897-2422145 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References