271173

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4395711..4396492 Replicon chromosome
Accession NZ_CP117400
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM014

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag PQP96_RS21625 Protein ID WP_000626099.1
Coordinates 4395711..4396202 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PQP96_RS21630 Protein ID WP_001110452.1
Coordinates 4396199..4396492 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP96_RS21590 (4391706) 4391706..4392281 + 576 WP_001188509.1 transcriptional regulator -
PQP96_RS21600 (4392552) 4392552..4392629 - 78 Protein_4221 helix-turn-helix domain-containing protein -
PQP96_RS21605 (4392720) 4392720..4393052 - 333 WP_001165471.1 MerR family transcriptional regulator -
PQP96_RS21610 (4393124) 4393124..4393501 + 378 WP_000916345.1 EthD family reductase -
PQP96_RS21615 (4394534) 4394534..4394608 + 75 Protein_4224 porin family protein -
PQP96_RS21620 (4394711) 4394711..4395463 + 753 WP_000842434.1 non-specific acid phosphatase -
PQP96_RS21625 (4395711) 4395711..4396202 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
PQP96_RS21630 (4396199) 4396199..4396492 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PQP96_RS21635 (4396809) 4396809..4397030 + 222 WP_001576552.1 hypothetical protein -
PQP96_RS21640 (4397295) 4397295..4398170 + 876 WP_000921674.1 AraC family transcriptional regulator -
PQP96_RS21645 (4398167) 4398167..4398454 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP96_RS21650 (4398477) 4398477..4398692 + 216 WP_001595136.1 hypothetical protein -
PQP96_RS21655 (4398700) 4398700..4398969 + 270 WP_010989096.1 hypothetical protein -
PQP96_RS21660 (4399178) 4399178..4399636 - 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
PQP96_RS21665 (4399975) 4399975..4400880 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4399178..4399636 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T271173 WP_000626099.1 NZ_CP117400:c4396202-4395711 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT271173 WP_001110452.1 NZ_CP117400:c4396492-4396199 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References