Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2475165..2475687 Replicon chromosome
Accession NZ_CP117400
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM014

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQP96_RS12170 Protein ID WP_000221343.1
Coordinates 2475403..2475687 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP96_RS12165 Protein ID WP_000885424.1
Coordinates 2475165..2475413 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP96_RS12140 (2470381) 2470381..2471847 + 1467 WP_000987828.1 hypothetical protein -
PQP96_RS12145 (2472655) 2472655..2473369 + 715 Protein_2376 helix-turn-helix domain-containing protein -
PQP96_RS12150 (2473425) 2473425..2474333 - 909 WP_010989018.1 hypothetical protein -
PQP96_RS12155 (2474476) 2474476..2474808 - 333 WP_000253154.1 DUF1493 family protein -
PQP96_RS12160 (2474798) 2474798..2475013 - 216 WP_000206207.1 hypothetical protein -
PQP96_RS12165 (2475165) 2475165..2475413 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP96_RS12170 (2475403) 2475403..2475687 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP96_RS12175 (2475858) 2475858..2476247 + 390 WP_000194089.1 RidA family protein -
PQP96_RS12180 (2476299) 2476299..2477378 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP96_RS12185 (2477571) 2477571..2478059 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP96_RS12190 (2478104) 2478104..2479612 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2470384..2482469 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T271167 WP_000221343.1 NZ_CP117400:2475403-2475687 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT271167 WP_000885424.1 NZ_CP117400:2475165-2475413 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References