Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4716726..4717328 Replicon chromosome
Accession NZ_CP117398
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM015

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQQ09_RS23055 Protein ID WP_001159630.1
Coordinates 4717017..4717328 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ09_RS23050 Protein ID WP_000362050.1
Coordinates 4716726..4717016 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ09_RS23035 (4714219) 4714219..4715121 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQQ09_RS23040 (4715118) 4715118..4715753 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ09_RS23045 (4715750) 4715750..4716679 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ09_RS23050 (4716726) 4716726..4717016 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ09_RS23055 (4717017) 4717017..4717328 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ09_RS23060 (4717546) 4717546..4718475 + 930 WP_001127703.1 alpha/beta hydrolase -
PQQ09_RS23065 (4718561) 4718561..4718872 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQQ09_RS23070 (4718869) 4718869..4719315 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ09_RS23075 (4719330) 4719330..4720271 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ09_RS23080 (4720316) 4720316..4720753 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PQQ09_RS23085 (4720750) 4720750..4721622 - 873 WP_000921427.1 virulence factor BrkB family protein -
PQQ09_RS23090 (4721616) 4721616..4722215 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T271154 WP_001159630.1 NZ_CP117398:c4717328-4717017 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT271154 WP_000362050.1 NZ_CP117398:c4717016-4716726 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References