Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1901171..1901831 Replicon chromosome
Accession NZ_CP117394
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM017

Toxin (Protein)


Gene name higB Uniprot ID A0A623V7Z2
Locus tag PQP77_RS09105 Protein ID WP_000269842.1
Coordinates 1901171..1901524 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP77_RS09110 Protein ID WP_000533827.1
Coordinates 1901529..1901831 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP77_RS09080 (1897236) 1897236..1897991 + 756 WP_001089670.1 multiubiquitin domain-containing protein -
PQP77_RS09085 (1897966) 1897966..1899150 + 1185 WP_076741638.1 ThiF family adenylyltransferase -
PQP77_RS09090 (1899144) 1899144..1899608 + 465 WP_001660343.1 DUF6527 family protein -
PQP77_RS09095 (1899989) 1899989..1900456 + 468 WP_000201266.1 hypothetical protein -
PQP77_RS09100 (1900453) 1900453..1900674 + 222 WP_000813787.1 helix-turn-helix transcriptional regulator -
PQP77_RS09105 (1901171) 1901171..1901524 + 354 WP_000269842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP77_RS09110 (1901529) 1901529..1901831 + 303 WP_000533827.1 XRE family transcriptional regulator Antitoxin
PQP77_RS09115 (1902337) 1902337..1903221 + 885 WP_000511750.1 integrase domain-containing protein -
PQP77_RS09120 (1904090) 1904090..1905352 - 1263 WP_076741637.1 integrase arm-type DNA-binding domain-containing protein -
PQP77_RS09130 (1905690) 1905690..1906487 - 798 WP_000598920.1 DgsA anti-repressor MtfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1882063..1911267 29204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13476.36 Da        Isoelectric Point: 9.9199

>T271097 WP_000269842.1 NZ_CP117394:1901171-1901524 [Salmonella enterica subsp. enterica serovar Uganda]
VWTIKTTDTFDRWFASLNDTNRVSVLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11040.81 Da        Isoelectric Point: 5.7316

>AT271097 WP_000533827.1 NZ_CP117394:1901529-1901831 [Salmonella enterica subsp. enterica serovar Uganda]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623V7Z2

Antitoxin

Source ID Structure

References