Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4451135..4451737 Replicon chromosome
Accession NZ_CP117392
Organism Salmonella enterica subsp. enterica serovar Give strain RM019

Toxin (Protein)


Gene name higB Uniprot ID A0A3V8XMR3
Locus tag PQQ03_RS21625 Protein ID WP_001159631.1
Coordinates 4451426..4451737 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ03_RS21620 Protein ID WP_000362050.1
Coordinates 4451135..4451425 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ03_RS21605 (4448628) 4448628..4449530 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQQ03_RS21610 (4449527) 4449527..4450162 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ03_RS21615 (4450159) 4450159..4451088 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ03_RS21620 (4451135) 4451135..4451425 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ03_RS21625 (4451426) 4451426..4451737 - 312 WP_001159631.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ03_RS21630 (4451955) 4451955..4452884 + 930 WP_001127691.1 alpha/beta hydrolase -
PQQ03_RS21635 (4452970) 4452970..4453281 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQQ03_RS21640 (4453278) 4453278..4453724 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ03_RS21645 (4453739) 4453739..4454680 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ03_RS21650 (4454725) 4454725..4455162 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PQQ03_RS21655 (4455159) 4455159..4456031 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ03_RS21660 (4456025) 4456025..4456624 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12312.25 Da        Isoelectric Point: 9.4460

>T271091 WP_001159631.1 NZ_CP117392:c4451737-4451426 [Salmonella enterica subsp. enterica serovar Give]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT271091 WP_000362050.1 NZ_CP117392:c4451425-4451135 [Salmonella enterica subsp. enterica serovar Give]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8XMR3

Antitoxin

Source ID Structure

References