Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4574318..4574920 Replicon chromosome
Accession NZ_CP117390
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM008

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQP88_RS22170 Protein ID WP_001159635.1
Coordinates 4574609..4574920 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP88_RS22165 Protein ID WP_000362050.1
Coordinates 4574318..4574608 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP88_RS22150 (4571811) 4571811..4572713 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQP88_RS22155 (4572710) 4572710..4573345 + 636 WP_274890473.1 formate dehydrogenase cytochrome b556 subunit -
PQP88_RS22160 (4573342) 4573342..4574271 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP88_RS22165 (4574318) 4574318..4574608 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP88_RS22170 (4574609) 4574609..4574920 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP88_RS22175 (4575138) 4575138..4576067 + 930 WP_001127706.1 alpha/beta hydrolase -
PQP88_RS22180 (4576153) 4576153..4576464 + 312 WP_000558162.1 type II toxin-antitoxin system HigB family toxin -
PQP88_RS22185 (4576461) 4576461..4576907 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
PQP88_RS22190 (4576922) 4576922..4577863 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP88_RS22195 (4577908) 4577908..4578345 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP88_RS22200 (4578342) 4578342..4579214 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP88_RS22205 (4579208) 4579208..4579807 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T271077 WP_001159635.1 NZ_CP117390:c4574920-4574609 [Salmonella enterica subsp. enterica serovar Uganda]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT271077 WP_000362050.1 NZ_CP117390:c4574608-4574318 [Salmonella enterica subsp. enterica serovar Uganda]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References