Detailed information of TA system TA027107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1826667..1827179
• Replicon: chromosome
• Accession: NC_017595
• Organism: Streptococcus salivarius JIM8777

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: W3XTH0
• Locus tag: SALIVA_RS08225
• Protein ID: WP_014634942.1
• Coordinates: 1826667..1826921 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: SALIVA_RS08230
• Protein ID: WP_013991075.1
• Coordinates: 1826925..1827179 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SALIVA_RS10625	1821907..1822074	-	168	WP_014634940.1	hypothetical protein	-
SALIVA_RS08215	1822649..1823257	-	609	WP_002884297.1	DUF4230 domain-containing protein	-
SALIVA_RS08220	1823836..1825941	-	2106	WP_014634941.1	ATP-dependent Clp protease ATP-binding subunit	-
SALIVA_RS08225	1826667..1826921	-	255	WP_014634942.1	Txe/YoeB family addiction module toxin	Toxin
SALIVA_RS08230	1826925..1827179	-	255	WP_013991075.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SALIVA_RS08235	1827321..1828412	-	1092	WP_014634944.1	nucleotidyltransferase	-
SALIVA_RS08240	1828419..1829159	-	741	WP_014634945.1	class I SAM-dependent methyltransferase	-
SALIVA_RS08245	1829364..1829717	-	354	WP_014632696.1	ribosome silencing factor	-
SALIVA_RS08250	1829741..1830331	-	591	WP_014634946.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
SALIVA_RS08255	1830328..1830960	-	633	WP_002884372.1	nicotinate-nucleotide adenylyltransferase	-
SALIVA_RS08260	1831068..1831385	-	318	WP_002884193.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10111.55 Da
• Isoelectric Point: 8.8499

>T27107 WP_014634942.1 NC_017595:c1826921-1826667 [Streptococcus salivarius JIM8777]
MLLTFTEDAWTDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMIDGKSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T27107 NC_017595:c1826921-1826667 [Streptococcus salivarius JIM8777]
ATGTTACTCACTTTTACTGAAGATGCATGGACAGATTATTGTTATTGGCAAAATCAAGATAGGAAGACCCTCAAGCGAAT
CAATAAATTAATTAAAGACATTCAACGGGATCCTTTTTCAGGTATTGGGAAGCCAGAACCCTTAAAGTATGACTTTCAAG
GAGCTTGGTCTCGACGAATTGATGCTGAAAATCGTTTGATTTATATGATTGATGGTAAGAGCGTCGCTTTTCTATCTTTT
AAAGATCATTATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9719.00 Da
• Isoelectric Point: 4.8782

>AT27107 WP_013991075.1 NC_017595:c1827179-1826925 [Streptococcus salivarius JIM8777]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGETQEH
AIKE

Nucleotide

• Length: 255 bp

>AT27107 NC_017595:c1827179-1826925 [Streptococcus salivarius JIM8777]
ATGGAAGCAGTCGTCTATTCAACGTTTCGAAATCATTTAAAGGATTATATGAAGAAGGTTAATGATGAGTTTGAACCTCT
AGCTGTAGTCAATAAAAATCCTGATGAAGATATTGTAGTGGTCTCAAAGAGTGAATGGGATAGCATTCAAGAAACATTGC
GTATTGTTCAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGGCTCAGGTACGTGCTGGAGAGACTCAAGAACAT
GCAATAAAGGAGTAG

Structures

Toxin

• AlphaFold DB: W3XTH0