Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4613863..4614465 Replicon chromosome
Accession NZ_CP117388
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM010

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQQ04_RS22485 Protein ID WP_001159635.1
Coordinates 4614154..4614465 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ04_RS22480 Protein ID WP_000362050.1
Coordinates 4613863..4614153 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ04_RS22465 (4611356) 4611356..4612258 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQQ04_RS22470 (4612255) 4612255..4612890 + 636 WP_274894956.1 formate dehydrogenase cytochrome b556 subunit -
PQQ04_RS22475 (4612887) 4612887..4613816 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ04_RS22480 (4613863) 4613863..4614153 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ04_RS22485 (4614154) 4614154..4614465 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ04_RS22490 (4614683) 4614683..4615612 + 930 WP_001127706.1 alpha/beta hydrolase -
PQQ04_RS22495 (4615698) 4615698..4616009 + 312 WP_000558162.1 type II toxin-antitoxin system HigB family toxin -
PQQ04_RS22500 (4616006) 4616006..4616452 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ04_RS22505 (4616467) 4616467..4617408 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ04_RS22510 (4617453) 4617453..4617890 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ04_RS22515 (4617887) 4617887..4618759 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ04_RS22520 (4618753) 4618753..4619352 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T271055 WP_001159635.1 NZ_CP117388:c4614465-4614154 [Salmonella enterica subsp. enterica serovar Uganda]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT271055 WP_000362050.1 NZ_CP117388:c4614153-4613863 [Salmonella enterica subsp. enterica serovar Uganda]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References