Detailed information of TA system TA027105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 1407926..1408583
• Replicon: chromosome
• Accession: NC_017594
• Organism: Streptococcus salivarius 57 I

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5C1JKZ1
• Locus tag: SSAL_RS06410
• Protein ID: WP_045001823.1
• Coordinates: 1408230..1408583 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SSAL_RS06405
• Protein ID: WP_014633320.1
• Coordinates: 1407926..1408228 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSAL_RS06395 (Ssal_01412)	1404107..1404760	-	654	WP_013990814.1	hypothetical protein	-
SSAL_RS06400 (Ssal_01413)	1404772..1407762	-	2991	WP_014633319.1	type I restriction endonuclease subunit R	-
SSAL_RS06405 (Ssal_01414)	1407926..1408228	-	303	WP_014633320.1	helix-turn-helix transcriptional regulator	Antitoxin
SSAL_RS06410	1408230..1408583	-	354	WP_045001823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SSAL_RS06415 (Ssal_01416)	1408820..1409584	-	765	WP_014633322.1	SDR family NAD(P)-dependent oxidoreductase	-
SSAL_RS06420 (Ssal_01417)	1409616..1410773	-	1158	WP_045001825.1	DUF2974 domain-containing protein	-
SSAL_RS06425 (Ssal_01418)	1410883..1411509	+	627	WP_004182761.1	Pr6Pr family membrane protein	-
SSAL_RS06430 (Ssal_01419)	1411547..1412389	-	843	WP_014633324.1	Cof-type HAD-IIB family hydrolase	-
SSAL_RS06435 (Ssal_01420)	1412541..1412930	+	390	WP_004182763.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1400878..1409584	8706

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-91)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 14056.43 Da
• Isoelectric Point: 10.3788

>T27105 WP_045001823.1 NC_017594:c1408583-1408230 [Streptococcus salivarius 57.I]
MYPIHFYKDRNGHEPVREYIETLSINSSKDSRIKLHKIQDYLTMLKNRGTMIGEPFIKHLEGEIWELRPLRDRILFAAWL
DDGFILLHHFVKKTQKTPRRELMKAQKALDDIRKRGL

Nucleotide

• Length: 354 bp

>T27105 NC_017594:c1408583-1408230 [Streptococcus salivarius 57.I]
ATGTATCCTATTCATTTTTATAAAGATAGAAATGGACATGAACCTGTTAGAGAGTATATTGAAACATTATCCATAAATTC
AAGCAAAGATTCTAGAATCAAATTACATAAAATTCAAGACTACCTGACTATGTTAAAAAATAGAGGAACCATGATTGGTG
AACCATTCATTAAACATTTGGAAGGAGAGATTTGGGAACTAAGACCCTTAAGAGATAGAATTTTATTTGCAGCATGGCTA
GATGATGGTTTTATTTTGCTTCATCATTTTGTGAAAAAGACACAAAAGACTCCAAGACGTGAGCTGATGAAGGCTCAAAA
AGCTTTAGATGATATTAGAAAGCGAGGATTGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10965.90 Da
• Isoelectric Point: 10.0976

>AT27105 WP_014633320.1 NC_017594:c1408228-1407926 [Streptococcus salivarius 57.I]
MAREKNPAIGSSWDDLQKTIFTKEEIAASELRVALMLEIIDARKKQGISQKKLEELSGVKQPVIARMETGKTAPQLDTVL
KILASLGKTLAVVPLDSHVK

Nucleotide

• Length: 303 bp

>AT27105 NC_017594:c1408228-1407926 [Streptococcus salivarius 57.I]
ATGGCTCGAGAAAAGAATCCAGCAATTGGAAGTAGTTGGGATGATTTACAGAAAACTATTTTCACTAAAGAGGAAATCGC
GGCAAGTGAACTCCGTGTCGCACTGATGCTTGAGATTATTGATGCTCGTAAAAAACAAGGCATTTCTCAAAAGAAACTTG
AAGAGCTAAGTGGTGTCAAACAACCTGTTATCGCACGTATGGAGACAGGTAAAACAGCACCTCAGTTAGATACGGTTCTT
AAAATACTGGCGAGTCTAGGTAAGACATTGGCGGTAGTCCCACTTGATTCACATGTGAAGTAA

Structures

Toxin

• AlphaFold DB: A0A5C1JKZ1