Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1901284..1901944 Replicon chromosome
Accession NZ_CP117388
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM010

Toxin (Protein)


Gene name higB Uniprot ID A0A623V7Z2
Locus tag PQQ04_RS09105 Protein ID WP_000269842.1
Coordinates 1901284..1901637 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ04_RS09110 Protein ID WP_000533827.1
Coordinates 1901642..1901944 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ04_RS09080 (1897349) 1897349..1898104 + 756 WP_001089670.1 multiubiquitin domain-containing protein -
PQQ04_RS09085 (1898079) 1898079..1899263 + 1185 WP_076741638.1 ThiF family adenylyltransferase -
PQQ04_RS09090 (1899257) 1899257..1899721 + 465 WP_001660343.1 DUF6527 family protein -
PQQ04_RS09095 (1900102) 1900102..1900569 + 468 WP_000201266.1 hypothetical protein -
PQQ04_RS09100 (1900566) 1900566..1900787 + 222 WP_000813787.1 helix-turn-helix transcriptional regulator -
PQQ04_RS09105 (1901284) 1901284..1901637 + 354 WP_000269842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ04_RS09110 (1901642) 1901642..1901944 + 303 WP_000533827.1 XRE family transcriptional regulator Antitoxin
PQQ04_RS09115 (1902450) 1902450..1903334 + 885 WP_000511750.1 integrase domain-containing protein -
PQQ04_RS09120 (1904203) 1904203..1905465 - 1263 WP_076741637.1 integrase arm-type DNA-binding domain-containing protein -
PQQ04_RS09130 (1905803) 1905803..1906600 - 798 WP_000598920.1 DgsA anti-repressor MtfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1882176..1911380 29204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13476.36 Da        Isoelectric Point: 9.9199

>T271040 WP_000269842.1 NZ_CP117388:1901284-1901637 [Salmonella enterica subsp. enterica serovar Uganda]
VWTIKTTDTFDRWFASLNDTNRVSVLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11040.81 Da        Isoelectric Point: 5.7316

>AT271040 WP_000533827.1 NZ_CP117388:1901642-1901944 [Salmonella enterica subsp. enterica serovar Uganda]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623V7Z2

Antitoxin

Source ID Structure

References