Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4613383..4613985 Replicon chromosome
Accession NZ_CP117386
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM011

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQP90_RS22495 Protein ID WP_001159635.1
Coordinates 4613674..4613985 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP90_RS22490 Protein ID WP_000362050.1
Coordinates 4613383..4613673 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP90_RS22475 (4610876) 4610876..4611778 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQP90_RS22480 (4611775) 4611775..4612410 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
PQP90_RS22485 (4612407) 4612407..4613336 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP90_RS22490 (4613383) 4613383..4613673 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP90_RS22495 (4613674) 4613674..4613985 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP90_RS22500 (4614203) 4614203..4615132 + 930 WP_001127706.1 alpha/beta hydrolase -
PQP90_RS22505 (4615218) 4615218..4615529 + 312 WP_000558162.1 type II toxin-antitoxin system HigB family toxin -
PQP90_RS22510 (4615526) 4615526..4615972 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
PQP90_RS22515 (4615987) 4615987..4616928 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP90_RS22520 (4616973) 4616973..4617410 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP90_RS22525 (4617407) 4617407..4618279 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP90_RS22530 (4618273) 4618273..4618872 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T271033 WP_001159635.1 NZ_CP117386:c4613985-4613674 [Salmonella enterica subsp. enterica serovar Uganda]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT271033 WP_000362050.1 NZ_CP117386:c4613673-4613383 [Salmonella enterica subsp. enterica serovar Uganda]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References