Detailed information of TA system TA027103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 381197..381709
• Replicon: chromosome
• Accession: NC_017594
• Organism: Streptococcus salivarius 57 I

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: F8HFZ9
• Locus tag: SSAL_RS01965
• Protein ID: WP_008535398.1
• Coordinates: 381455..381709 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: SSAL_RS01960
• Protein ID: WP_013991075.1
• Coordinates: 381197..381451 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SSAL_RS01930 (Ssal_00416)	376994..377311	+	318	WP_002884193.1	ribosome assembly RNA-binding protein YhbY	-
SSAL_RS01935 (Ssal_00417)	377419..378051	+	633	WP_002884372.1	nicotinate-nucleotide adenylyltransferase	-
SSAL_RS01940 (Ssal_00418)	378048..378638	+	591	WP_014632695.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
SSAL_RS01945 (Ssal_00419)	378661..379014	+	354	WP_014632696.1	ribosome silencing factor	-
SSAL_RS01950 (Ssal_00420)	379219..379959	+	741	WP_013991077.1	class I SAM-dependent methyltransferase	-
SSAL_RS01955 (Ssal_00421)	379965..381056	+	1092	WP_013991076.1	nucleotidyltransferase	-
SSAL_RS01960 (Ssal_00422)	381197..381451	+	255	WP_013991075.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SSAL_RS01965 (Ssal_00423)	381455..381709	+	255	WP_008535398.1	Txe/YoeB family addiction module toxin	Toxin
SSAL_RS01970 (Ssal_00425)	382414..384519	+	2106	WP_013991074.1	ATP-dependent Clp protease ATP-binding subunit	-
SSAL_RS01975 (Ssal_00427)	385098..385706	+	609	WP_013991073.1	DUF4230 domain-containing protein	-
SSAL_RS10180 (Ssal_00428)	386283..386450	+	168	WP_014632697.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10097.52 Da
• Isoelectric Point: 8.8499

>T27103 WP_008535398.1 NC_017594:381455-381709 [Streptococcus salivarius 57.I]
MLLTFTEDAWTDYCYWQNQDRKTLKRINKLIKDIQRDPFSGIGKPEPLKYDFQGAWSRRIDAENRLIYMVDGKSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T27103 NC_017594:381455-381709 [Streptococcus salivarius 57.I]
ATGTTACTCACTTTTACTGAAGATGCATGGACAGATTATTGTTATTGGCAAAATCAAGATAGGAAGACACTTAAGCGAAT
CAATAAGCTGATTAAAGACATTCAACGGGATCCTTTTTCAGGTATTGGGAAACCAGAACCCTTGAAGTATGACTTTCAAG
GAGCTTGGTCTCGACGAATTGATGCTGAAAATCGTTTGATTTATATGGTTGATGGTAAGAGTGTCGCCTTTCTCTCTTTC
AAAGATCATTATTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9719.00 Da
• Isoelectric Point: 4.8782

>AT27103 WP_013991075.1 NC_017594:381197-381451 [Streptococcus salivarius 57.I]
MEAVVYSTFRNHLKDYMKKVNDEFEPLAVVNKNPDEDIVVVSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGETQEH
AIKE

Nucleotide

• Length: 255 bp

>AT27103 NC_017594:381197-381451 [Streptococcus salivarius 57.I]
ATGGAAGCAGTCGTCTATTCAACATTTCGAAATCATTTAAAGGATTATATGAAGAAGGTTAATGATGAATTTGAACCTCT
AGCTGTAGTCAATAAAAATCCTGATGAAGATATTGTAGTGGTCTCAAAGAGTGAATGGGATAGCATTCAAGAAACATTGC
GTATTGTTCAAAATAAAGAACTATCAGACAAGGTTTTAAGAGGAATGGCTCAGGTACGTGCTGGAGAGACTCAAGAACAT
GCAATAAAGGAGTAG

Structures

Toxin

• AlphaFold DB: F8HFZ9