Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2591284..2591944 Replicon chromosome
Accession NZ_CP117386
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM011

Toxin (Protein)


Gene name higB Uniprot ID A0A623V7Z2
Locus tag PQP90_RS12785 Protein ID WP_000269842.1
Coordinates 2591591..2591944 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP90_RS12780 Protein ID WP_000533827.1
Coordinates 2591284..2591586 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP90_RS12760 (2586628) 2586628..2587425 + 798 WP_000598920.1 DgsA anti-repressor MtfA -
PQP90_RS12770 (2587763) 2587763..2589025 + 1263 WP_076741637.1 integrase arm-type DNA-binding domain-containing protein -
PQP90_RS12775 (2589894) 2589894..2590778 - 885 WP_000511750.1 integrase domain-containing protein -
PQP90_RS12780 (2591284) 2591284..2591586 - 303 WP_000533827.1 XRE family transcriptional regulator Antitoxin
PQP90_RS12785 (2591591) 2591591..2591944 - 354 WP_000269842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP90_RS12790 (2592441) 2592441..2592662 - 222 WP_000813787.1 helix-turn-helix transcriptional regulator -
PQP90_RS12795 (2592659) 2592659..2593126 - 468 WP_000201266.1 hypothetical protein -
PQP90_RS12800 (2593507) 2593507..2593971 - 465 WP_001660343.1 DUF6527 family protein -
PQP90_RS12805 (2593965) 2593965..2595149 - 1185 WP_076741638.1 ThiF family adenylyltransferase -
PQP90_RS12810 (2595124) 2595124..2595879 - 756 WP_001089670.1 multiubiquitin domain-containing protein -
PQP90_RS12815 (2595967) 2595967..2596572 - 606 WP_274897597.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2578608..2599351 20743


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13476.36 Da        Isoelectric Point: 9.9199

>T271023 WP_000269842.1 NZ_CP117386:c2591944-2591591 [Salmonella enterica subsp. enterica serovar Uganda]
VWTIKTTDTFDRWFASLNDTNRVSVLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11040.81 Da        Isoelectric Point: 5.7316

>AT271023 WP_000533827.1 NZ_CP117386:c2591586-2591284 [Salmonella enterica subsp. enterica serovar Uganda]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623V7Z2

Antitoxin

Source ID Structure

References