27101

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1592542..1593054 Replicon chromosome
Accession NC_017593
Organism Streptococcus pneumoniae INV200

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag SPNINV200_RS08320 Protein ID WP_000924721.1
Coordinates 1592542..1592796 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag SPNINV200_RS08325 Protein ID WP_000388572.1
Coordinates 1592800..1593054 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPNINV200_RS08305 1589643..1589957 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
SPNINV200_RS08310 1589982..1590608 - 627 WP_000775037.1 guanylate kinase -
SPNINV200_RS08315 1590738..1592351 - 1614 WP_000404940.1 ribonuclease Y -
SPNINV200_RS08320 1592542..1592796 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
SPNINV200_RS08325 1592800..1593054 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SPNINV200_RS08330 1593292..1594389 - 1098 WP_000156330.1 nucleotidyltransferase -
SPNINV200_RS08335 1594399..1595145 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
SPNINV200_RS08340 1595248..1595601 - 354 WP_001003001.1 ribosome silencing factor -
SPNINV200_RS08345 1595614..1596114 - 501 WP_000844713.1 cysteine hydrolase -
SPNINV200_RS08350 1596115..1596708 - 594 WP_000121651.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
SPNINV200_RS08355 1596708..1597337 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
SPNINV200_RS08360 1597389..1597700 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T27101 WP_000924721.1 NC_017593:c1592796-1592542 [Streptococcus pneumoniae INV200]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T27101 NC_017593:c1592796-1592542 [Streptococcus pneumoniae INV200]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT27101 WP_000388572.1 NC_017593:c1593054-1592800 [Streptococcus pneumoniae INV200]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT27101 NC_017593:c1593054-1592800 [Streptococcus pneumoniae INV200]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References