Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1901107..1901767 Replicon chromosome
Accession NZ_CP117382
Organism Salmonella enterica subsp. enterica serovar Uganda strain RM018

Toxin (Protein)


Gene name higB Uniprot ID A0A623V7Z2
Locus tag PQP98_RS09090 Protein ID WP_000269842.1
Coordinates 1901107..1901460 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP98_RS09095 Protein ID WP_000533827.1
Coordinates 1901465..1901767 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP98_RS09065 (1897172) 1897172..1897927 + 756 WP_001089670.1 multiubiquitin domain-containing protein -
PQP98_RS09070 (1897902) 1897902..1899086 + 1185 WP_076741638.1 ThiF family adenylyltransferase -
PQP98_RS09075 (1899080) 1899080..1899544 + 465 WP_001660343.1 DUF6527 family protein -
PQP98_RS09080 (1899925) 1899925..1900392 + 468 WP_000201266.1 hypothetical protein -
PQP98_RS09085 (1900389) 1900389..1900610 + 222 WP_000813787.1 helix-turn-helix transcriptional regulator -
PQP98_RS09090 (1901107) 1901107..1901460 + 354 WP_000269842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP98_RS09095 (1901465) 1901465..1901767 + 303 WP_000533827.1 XRE family transcriptional regulator Antitoxin
PQP98_RS09100 (1902273) 1902273..1903157 + 885 WP_000511750.1 integrase domain-containing protein -
PQP98_RS09105 (1904026) 1904026..1905288 - 1263 WP_076741637.1 integrase arm-type DNA-binding domain-containing protein -
PQP98_RS09115 (1905626) 1905626..1906423 - 798 WP_000598920.1 DgsA anti-repressor MtfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1881999..1911203 29204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13476.36 Da        Isoelectric Point: 9.9199

>T270974 WP_000269842.1 NZ_CP117382:1901107-1901460 [Salmonella enterica subsp. enterica serovar Uganda]
VWTIKTTDTFDRWFASLNDTNRVSVLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGEPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11040.81 Da        Isoelectric Point: 5.7316

>AT270974 WP_000533827.1 NZ_CP117382:1901465-1901767 [Salmonella enterica subsp. enterica serovar Uganda]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A623V7Z2

Antitoxin

Source ID Structure

References