Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4651021..4651623 Replicon chromosome
Accession NZ_CP117380
Organism Salmonella enterica subsp. enterica serovar Newport strain RM037

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQP93_RS22755 Protein ID WP_001159630.1
Coordinates 4651312..4651623 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP93_RS22750 Protein ID WP_000362050.1
Coordinates 4651021..4651311 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP93_RS22735 (4648514) 4648514..4649416 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQP93_RS22740 (4649413) 4649413..4650048 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP93_RS22745 (4650045) 4650045..4650974 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP93_RS22750 (4651021) 4651021..4651311 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP93_RS22755 (4651312) 4651312..4651623 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP93_RS22760 (4651841) 4651841..4652770 + 930 WP_001127704.1 alpha/beta hydrolase -
PQP93_RS22765 (4652856) 4652856..4653166 + 311 Protein_4445 type II toxin-antitoxin system HigB family toxin -
PQP93_RS22770 (4653163) 4653163..4653609 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP93_RS22775 (4653624) 4653624..4654565 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP93_RS22780 (4654610) 4654610..4655047 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP93_RS22785 (4655044) 4655044..4655916 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP93_RS22790 (4655910) 4655910..4656509 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270968 WP_001159630.1 NZ_CP117380:c4651623-4651312 [Salmonella enterica subsp. enterica serovar Newport]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270968 WP_000362050.1 NZ_CP117380:c4651311-4651021 [Salmonella enterica subsp. enterica serovar Newport]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References