Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4644359..4644961 Replicon chromosome
Accession NZ_CP117376
Organism Salmonella enterica subsp. enterica serovar Newport strain RM041

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQQ16_RS22690 Protein ID WP_001159630.1
Coordinates 4644650..4644961 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ16_RS22685 Protein ID WP_000362050.1
Coordinates 4644359..4644649 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ16_RS22670 (4641852) 4641852..4642754 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQQ16_RS22675 (4642751) 4642751..4643386 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ16_RS22680 (4643383) 4643383..4644312 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ16_RS22685 (4644359) 4644359..4644649 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ16_RS22690 (4644650) 4644650..4644961 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ16_RS22695 (4645179) 4645179..4646108 + 930 WP_001127704.1 alpha/beta hydrolase -
PQQ16_RS22700 (4646194) 4646194..4646504 + 311 Protein_4432 type II toxin-antitoxin system HigB family toxin -
PQQ16_RS22705 (4646501) 4646501..4646947 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ16_RS22710 (4646962) 4646962..4647903 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ16_RS22715 (4647948) 4647948..4648385 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ16_RS22720 (4648382) 4648382..4649254 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ16_RS22725 (4649248) 4649248..4649847 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270937 WP_001159630.1 NZ_CP117376:c4644961-4644650 [Salmonella enterica subsp. enterica serovar Newport]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270937 WP_000362050.1 NZ_CP117376:c4644649-4644359 [Salmonella enterica subsp. enterica serovar Newport]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References