Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4659832..4660434 Replicon chromosome
Accession NZ_CP117373
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM043

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQQ08_RS22870 Protein ID WP_001159635.1
Coordinates 4660123..4660434 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ08_RS22865 Protein ID WP_000362050.1
Coordinates 4659832..4660122 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ08_RS22850 (4657325) 4657325..4658227 + 903 WP_000331367.1 formate dehydrogenase subunit beta -
PQQ08_RS22855 (4658224) 4658224..4658859 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ08_RS22860 (4658856) 4658856..4659785 + 930 WP_000027737.1 formate dehydrogenase accessory protein FdhE -
PQQ08_RS22865 (4659832) 4659832..4660122 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ08_RS22870 (4660123) 4660123..4660434 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ08_RS22875 (4660652) 4660652..4661581 + 930 WP_001127708.1 alpha/beta hydrolase -
PQQ08_RS22880 (4661667) 4661667..4661978 + 312 WP_000558169.1 type II toxin-antitoxin system HigB family toxin -
PQQ08_RS22885 (4661975) 4661975..4662421 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ08_RS22890 (4662436) 4662436..4663377 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ08_RS22895 (4663422) 4663422..4663859 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ08_RS22900 (4663856) 4663856..4664728 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ08_RS22905 (4664722) 4664722..4665321 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T270918 WP_001159635.1 NZ_CP117373:c4660434-4660123 [Salmonella enterica subsp. enterica serovar Dublin]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270918 WP_000362050.1 NZ_CP117373:c4660122-4659832 [Salmonella enterica subsp. enterica serovar Dublin]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References