Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 357999..358537 Replicon chromosome
Accession NZ_CP117373
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM043

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag PQQ08_RS01630 Protein ID WP_001526148.1
Coordinates 358262..358537 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag PQQ08_RS01625 Protein ID WP_000729713.1
Coordinates 357999..358259 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ08_RS01610 (353760) 353760..355313 + 1554 WP_000013013.1 TROVE domain-containing protein -
PQQ08_RS01615 (355661) 355661..356875 + 1215 WP_052895987.1 RNA-splicing ligase RtcB -
PQQ08_RS01620 (356879) 356879..357890 + 1012 Protein_319 RNA 3'-terminal phosphate cyclase -
PQQ08_RS01625 (357999) 357999..358259 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ08_RS01630 (358262) 358262..358537 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
PQQ08_RS01635 (358625) 358625..361330 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T270903 WP_001526148.1 NZ_CP117373:358262-358537 [Salmonella enterica subsp. enterica serovar Dublin]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT270903 WP_000729713.1 NZ_CP117373:357999-358259 [Salmonella enterica subsp. enterica serovar Dublin]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References