Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4644115..4644717 Replicon chromosome
Accession NZ_CP117371
Organism Salmonella enterica subsp. enterica serovar Newport strain RM049

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQQ06_RS22705 Protein ID WP_001159630.1
Coordinates 4644406..4644717 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ06_RS22700 Protein ID WP_000362050.1
Coordinates 4644115..4644405 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ06_RS22685 (4641608) 4641608..4642510 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQQ06_RS22690 (4642507) 4642507..4643142 + 636 WP_050943431.1 formate dehydrogenase cytochrome b556 subunit -
PQQ06_RS22695 (4643139) 4643139..4644068 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ06_RS22700 (4644115) 4644115..4644405 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ06_RS22705 (4644406) 4644406..4644717 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ06_RS22710 (4644935) 4644935..4645864 + 930 WP_001127704.1 alpha/beta hydrolase -
PQQ06_RS22715 (4645950) 4645950..4646261 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQQ06_RS22720 (4646258) 4646258..4646704 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ06_RS22725 (4646719) 4646719..4647660 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ06_RS22730 (4647705) 4647705..4648142 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ06_RS22735 (4648139) 4648139..4649011 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ06_RS22740 (4649005) 4649005..4649604 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270898 WP_001159630.1 NZ_CP117371:c4644717-4644406 [Salmonella enterica subsp. enterica serovar Newport]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270898 WP_000362050.1 NZ_CP117371:c4644405-4644115 [Salmonella enterica subsp. enterica serovar Newport]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References