Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4801864..4802466 Replicon chromosome
Accession NZ_CP117370
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain RM054

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQP97_RS23580 Protein ID WP_001159630.1
Coordinates 4802155..4802466 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP97_RS23575 Protein ID WP_000362050.1
Coordinates 4801864..4802154 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP97_RS23560 (4799357) 4799357..4800259 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQP97_RS23565 (4800256) 4800256..4800891 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP97_RS23570 (4800888) 4800888..4801817 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP97_RS23575 (4801864) 4801864..4802154 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP97_RS23580 (4802155) 4802155..4802466 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP97_RS23585 (4802684) 4802684..4803613 + 930 WP_001127703.1 alpha/beta hydrolase -
PQP97_RS23590 (4803699) 4803699..4804010 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQP97_RS23595 (4804007) 4804007..4804453 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP97_RS23600 (4804468) 4804468..4805409 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP97_RS23605 (4805454) 4805454..4805891 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PQP97_RS23610 (4805888) 4805888..4806760 - 873 WP_000921427.1 virulence factor BrkB family protein -
PQP97_RS23615 (4806754) 4806754..4807353 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270884 WP_001159630.1 NZ_CP117370:c4802466-4802155 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270884 WP_000362050.1 NZ_CP117370:c4802154-4801864 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References