Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4652881..4653483 Replicon chromosome
Accession NZ_CP117362
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM092

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQQ00_RS22800 Protein ID WP_001159635.1
Coordinates 4653172..4653483 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ00_RS22795 Protein ID WP_000362050.1
Coordinates 4652881..4653171 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ00_RS22780 (4650374) 4650374..4651276 + 903 WP_000331367.1 formate dehydrogenase subunit beta -
PQQ00_RS22785 (4651273) 4651273..4651908 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ00_RS22790 (4651905) 4651905..4652834 + 930 WP_000027737.1 formate dehydrogenase accessory protein FdhE -
PQQ00_RS22795 (4652881) 4652881..4653171 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ00_RS22800 (4653172) 4653172..4653483 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ00_RS22805 (4653701) 4653701..4654630 + 930 WP_001127708.1 alpha/beta hydrolase -
PQQ00_RS22810 (4654716) 4654716..4655027 + 312 WP_000558169.1 type II toxin-antitoxin system HigB family toxin -
PQQ00_RS22815 (4655024) 4655024..4655470 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ00_RS22820 (4655485) 4655485..4656426 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ00_RS22825 (4656471) 4656471..4656908 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ00_RS22830 (4656905) 4656905..4657777 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ00_RS22835 (4657771) 4657771..4658370 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T270822 WP_001159635.1 NZ_CP117362:c4653483-4653172 [Salmonella enterica subsp. enterica serovar Dublin]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270822 WP_000362050.1 NZ_CP117362:c4653171-4652881 [Salmonella enterica subsp. enterica serovar Dublin]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References