Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4666864..4667466 Replicon chromosome
Accession NZ_CP117357
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM096

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQQ15_RS22690 Protein ID WP_001159630.1
Coordinates 4667155..4667466 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ15_RS22685 Protein ID WP_000362050.1
Coordinates 4666864..4667154 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ15_RS22670 (4664357) 4664357..4665259 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQQ15_RS22675 (4665256) 4665256..4665891 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ15_RS22680 (4665888) 4665888..4666817 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ15_RS22685 (4666864) 4666864..4667154 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ15_RS22690 (4667155) 4667155..4667466 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ15_RS22695 (4667684) 4667684..4668613 + 930 WP_001127703.1 alpha/beta hydrolase -
PQQ15_RS22700 (4668699) 4668699..4669010 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQQ15_RS22705 (4669007) 4669007..4669453 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ15_RS22710 (4669468) 4669468..4670409 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ15_RS22715 (4670454) 4670454..4670891 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PQQ15_RS22720 (4670888) 4670888..4671760 - 873 WP_000921427.1 virulence factor BrkB family protein -
PQQ15_RS22725 (4671754) 4671754..4672353 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270779 WP_001159630.1 NZ_CP117357:c4667466-4667155 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270779 WP_000362050.1 NZ_CP117357:c4667154-4666864 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References