270772

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2467742..2468264 Replicon chromosome
Accession NZ_CP117357
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM096

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQQ15_RS12140 Protein ID WP_000221343.1
Coordinates 2467980..2468264 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQQ15_RS12135 Protein ID WP_000885424.1
Coordinates 2467742..2467990 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ15_RS12110 (2462960) 2462960..2464424 + 1465 Protein_2368 hypothetical protein -
PQQ15_RS12115 (2465232) 2465232..2465946 + 715 Protein_2369 helix-turn-helix domain-containing protein -
PQQ15_RS12120 (2466002) 2466002..2466910 - 909 WP_010989018.1 hypothetical protein -
PQQ15_RS12125 (2467053) 2467053..2467385 - 333 WP_000253154.1 DUF1493 family protein -
PQQ15_RS12130 (2467375) 2467375..2467590 - 216 WP_000206207.1 hypothetical protein -
PQQ15_RS12135 (2467742) 2467742..2467990 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ15_RS12140 (2467980) 2467980..2468264 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ15_RS12145 (2468435) 2468435..2468824 + 390 WP_000194089.1 RidA family protein -
PQQ15_RS12150 (2468876) 2468876..2469955 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQQ15_RS12155 (2470147) 2470147..2470635 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQQ15_RS12160 (2470680) 2470680..2472188 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2462963..2475045 12082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270772 WP_000221343.1 NZ_CP117357:2467980-2468264 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270772 WP_000885424.1 NZ_CP117357:2467742-2467990 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References