Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4652106..4652708 Replicon chromosome
Accession NZ_CP117354
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM099

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQP84_RS22795 Protein ID WP_001159635.1
Coordinates 4652397..4652708 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP84_RS22790 Protein ID WP_000362050.1
Coordinates 4652106..4652396 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP84_RS22775 (4649599) 4649599..4650501 + 903 WP_000331367.1 formate dehydrogenase subunit beta -
PQP84_RS22780 (4650498) 4650498..4651133 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP84_RS22785 (4651130) 4651130..4652059 + 930 WP_000027737.1 formate dehydrogenase accessory protein FdhE -
PQP84_RS22790 (4652106) 4652106..4652396 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP84_RS22795 (4652397) 4652397..4652708 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP84_RS22800 (4652926) 4652926..4653855 + 930 WP_001127708.1 alpha/beta hydrolase -
PQP84_RS22805 (4653941) 4653941..4654252 + 312 WP_000558169.1 type II toxin-antitoxin system HigB family toxin -
PQP84_RS22810 (4654249) 4654249..4654695 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
PQP84_RS22815 (4654710) 4654710..4655651 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP84_RS22820 (4655696) 4655696..4656133 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP84_RS22825 (4656130) 4656130..4657002 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP84_RS22830 (4656996) 4656996..4657595 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T270756 WP_001159635.1 NZ_CP117354:c4652708-4652397 [Salmonella enterica subsp. enterica serovar Dublin]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270756 WP_000362050.1 NZ_CP117354:c4652396-4652106 [Salmonella enterica subsp. enterica serovar Dublin]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References