Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4647209..4647811 Replicon chromosome
Accession NZ_CP117351
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM100

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQQ10_RS22790 Protein ID WP_001159635.1
Coordinates 4647500..4647811 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ10_RS22785 Protein ID WP_000362050.1
Coordinates 4647209..4647499 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ10_RS22770 (4644705) 4644705..4645607 + 903 WP_000331367.1 formate dehydrogenase subunit beta -
PQQ10_RS22775 (4645604) 4645604..4646236 + 633 WP_274896031.1 formate dehydrogenase cytochrome b556 subunit -
PQQ10_RS22780 (4646233) 4646233..4647162 + 930 WP_000027737.1 formate dehydrogenase accessory protein FdhE -
PQQ10_RS22785 (4647209) 4647209..4647499 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ10_RS22790 (4647500) 4647500..4647811 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ10_RS22795 (4648029) 4648029..4648958 + 930 WP_001127708.1 alpha/beta hydrolase -
PQQ10_RS22800 (4649044) 4649044..4649355 + 312 WP_000558169.1 type II toxin-antitoxin system HigB family toxin -
PQQ10_RS22805 (4649352) 4649352..4649798 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ10_RS22810 (4649813) 4649813..4650754 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ10_RS22815 (4650799) 4650799..4651236 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ10_RS22820 (4651233) 4651233..4652105 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ10_RS22825 (4652099) 4652099..4652698 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T270733 WP_001159635.1 NZ_CP117351:c4647811-4647500 [Salmonella enterica subsp. enterica serovar Dublin]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270733 WP_000362050.1 NZ_CP117351:c4647499-4647209 [Salmonella enterica subsp. enterica serovar Dublin]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References