270709

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4588011..4588613 Replicon chromosome
Accession NZ_CP117348
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain RM101

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQQ11_RS22250 Protein ID WP_001159635.1
Coordinates 4588302..4588613 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ11_RS22245 Protein ID WP_000362050.1
Coordinates 4588011..4588301 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ11_RS22230 (4585504) 4585504..4586406 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQQ11_RS22235 (4586403) 4586403..4587038 + 636 WP_274896181.1 formate dehydrogenase cytochrome b556 subunit -
PQQ11_RS22240 (4587035) 4587035..4587964 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ11_RS22245 (4588011) 4588011..4588301 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ11_RS22250 (4588302) 4588302..4588613 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ11_RS22255 (4588831) 4588831..4589760 + 930 WP_001127705.1 alpha/beta hydrolase -
PQQ11_RS22260 (4589846) 4589846..4590157 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
PQQ11_RS22265 (4590154) 4590154..4590600 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ11_RS22270 (4590615) 4590615..4591556 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ11_RS22275 (4591601) 4591601..4592038 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ11_RS22280 (4592035) 4592035..4592907 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ11_RS22285 (4592901) 4592901..4593500 - 600 WP_000965702.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T270709 WP_001159635.1 NZ_CP117348:c4588613-4588302 [Salmonella enterica subsp. enterica serovar Heidelberg]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270709 WP_000362050.1 NZ_CP117348:c4588301-4588011 [Salmonella enterica subsp. enterica serovar Heidelberg]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References