Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4655559..4656161 Replicon chromosome
Accession NZ_CP117346
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM104

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQP85_RS22815 Protein ID WP_001159635.1
Coordinates 4655850..4656161 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP85_RS22810 Protein ID WP_000362050.1
Coordinates 4655559..4655849 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP85_RS22795 (4653052) 4653052..4653954 + 903 WP_000331367.1 formate dehydrogenase subunit beta -
PQP85_RS22800 (4653951) 4653951..4654586 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP85_RS22805 (4654583) 4654583..4655512 + 930 WP_000027737.1 formate dehydrogenase accessory protein FdhE -
PQP85_RS22810 (4655559) 4655559..4655849 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP85_RS22815 (4655850) 4655850..4656161 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP85_RS22820 (4656379) 4656379..4657308 + 930 WP_001127708.1 alpha/beta hydrolase -
PQP85_RS22825 (4657394) 4657394..4657705 + 312 WP_000558169.1 type II toxin-antitoxin system HigB family toxin -
PQP85_RS22830 (4657702) 4657702..4658148 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
PQP85_RS22835 (4658163) 4658163..4659104 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP85_RS22840 (4659149) 4659149..4659586 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP85_RS22845 (4659583) 4659583..4660455 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP85_RS22850 (4660449) 4660449..4661048 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T270689 WP_001159635.1 NZ_CP117346:c4656161-4655850 [Salmonella enterica subsp. enterica serovar Dublin]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270689 WP_000362050.1 NZ_CP117346:c4655849-4655559 [Salmonella enterica subsp. enterica serovar Dublin]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References