Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 93993..94726 Replicon plasmid pSBAL11701
Accession NC_017577
Organism Shewanella baltica OS117

Toxin (Protein)


Gene name higB Uniprot ID A0A7U4E3D1
Locus tag SBAL117_RS23545 Protein ID WP_014620401.1
Coordinates 94415..94726 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7U3ZFL0
Locus tag SBAL117_RS23540 Protein ID WP_014620400.1
Coordinates 93993..94409 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBAL117_RS23515 89560..89877 - 318 WP_014620397.1 hypothetical protein -
SBAL117_RS23525 90739..91317 + 579 WP_014615480.1 DUF2913 family protein -
SBAL117_RS23530 91778..92839 - 1062 WP_014620398.1 ATP-binding protein -
SBAL117_RS23535 92832..93476 - 645 WP_014620399.1 putative two-component system response regulatory protein -
SBAL117_RS23540 93993..94409 - 417 WP_014620400.1 transcriptional regulator Antitoxin
SBAL117_RS23545 94415..94726 - 312 WP_014620401.1 type II toxin-antitoxin system HigB family toxin Toxin
SBAL117_RS25725 94980..95129 + 150 WP_014620402.1 hypothetical protein -
SBAL117_RS23550 95262..95660 - 399 WP_014620403.1 H-NS histone family protein -
SBAL117_RS23555 96132..97460 + 1329 WP_014620404.1 DUF3560 domain-containing protein -
SBAL117_RS23560 97641..98309 - 669 WP_014620405.1 hypothetical protein -
SBAL117_RS23565 98306..98752 - 447 WP_014620406.1 diadenylate cyclase -
SBAL117_RS23570 98834..99466 - 633 WP_014620407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120153 120153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(3-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12242.81 Da        Isoelectric Point: 10.0148

>T27065 WP_014620401.1 NC_017577:c94726-94415 [Shewanella baltica OS117]
VHVISRKPFNDAAQKYPNDKDALVQTYSTLRSGTFTNPDDLRQVFPSLDNFKYRDKWWVIDVGGNNLRIIAFIEFRDNRM
YVKHVVSHADYSKLTDKYRRTKE

Download         Length: 312 bp

>T27065 NC_017577:c94726-94415 [Shewanella baltica OS117]
GTGCACGTTATTTCAAGAAAACCATTTAATGATGCCGCGCAAAAGTATCCTAATGATAAGGATGCCTTGGTACAAACATA
CAGTACCTTACGCAGTGGCACATTCACCAATCCTGATGATTTACGACAAGTCTTTCCGTCTTTAGATAACTTTAAATATC
GAGATAAATGGTGGGTAATTGATGTGGGTGGTAACAATCTACGCATTATCGCTTTCATCGAGTTCCGAGATAACAGGATG
TATGTGAAGCACGTGGTTAGCCATGCAGACTATAGCAAGCTGACTGATAAGTACCGTCGAACAAAGGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15446.64 Da        Isoelectric Point: 4.2543

>AT27065 WP_014620400.1 NC_017577:c94409-93993 [Shewanella baltica OS117]
MLPAACIEIREALAKVPYLAHIETQDDYEQALALMDDLVDDYDSNKFLIEMLSLSIERWEEQADEFAEFNAAIAEMDSGI
AVLKTLMAQYRLGVADLPELGSKSNVSKLLNAAEGKKLNRHHIEALSQRFGVPVSLFF

Download         Length: 417 bp

>AT27065 NC_017577:c94409-93993 [Shewanella baltica OS117]
ATGCTACCTGCTGCATGTATTGAAATTAGAGAAGCATTGGCCAAAGTGCCATACCTCGCTCACATTGAAACTCAGGACGA
CTACGAGCAAGCATTAGCATTAATGGACGATCTGGTTGATGATTACGACTCAAACAAGTTTTTGATTGAGATGTTGTCAC
TTAGCATTGAGCGATGGGAAGAGCAAGCGGATGAATTTGCTGAATTTAATGCAGCGATAGCCGAAATGGATAGTGGTATA
GCGGTATTGAAAACGCTTATGGCGCAGTATCGTCTTGGTGTTGCAGATCTTCCCGAATTAGGCTCAAAAAGTAATGTGAG
TAAGTTACTCAATGCCGCAGAAGGAAAGAAGCTTAATAGACACCACATTGAAGCACTCAGTCAGCGCTTTGGGGTGCCAG
TATCATTATTTTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4E3D1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3ZFL0

References