Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4650391..4650993 Replicon chromosome
Accession NZ_CP117340
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM111

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQQ02_RS22770 Protein ID WP_001159635.1
Coordinates 4650682..4650993 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ02_RS22765 Protein ID WP_000362050.1
Coordinates 4650391..4650681 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ02_RS22750 (4647884) 4647884..4648786 + 903 WP_000331367.1 formate dehydrogenase subunit beta -
PQQ02_RS22755 (4648783) 4648783..4649418 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQQ02_RS22760 (4649415) 4649415..4650344 + 930 WP_000027737.1 formate dehydrogenase accessory protein FdhE -
PQQ02_RS22765 (4650391) 4650391..4650681 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ02_RS22770 (4650682) 4650682..4650993 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ02_RS22775 (4651211) 4651211..4652140 + 930 WP_001127708.1 alpha/beta hydrolase -
PQQ02_RS22780 (4652226) 4652226..4652537 + 312 WP_000558169.1 type II toxin-antitoxin system HigB family toxin -
PQQ02_RS22785 (4652534) 4652534..4652980 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ02_RS22790 (4652995) 4652995..4653936 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ02_RS22795 (4653981) 4653981..4654418 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ02_RS22800 (4654415) 4654415..4655287 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ02_RS22805 (4655281) 4655281..4655880 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T270643 WP_001159635.1 NZ_CP117340:c4650993-4650682 [Salmonella enterica subsp. enterica serovar Dublin]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270643 WP_000362050.1 NZ_CP117340:c4650681-4650391 [Salmonella enterica subsp. enterica serovar Dublin]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References