270616

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2385965..2386487 Replicon chromosome
Accession NZ_CP117338
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM095

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQP94_RS11560 Protein ID WP_000221343.1
Coordinates 2386203..2386487 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP94_RS11555 Protein ID WP_000885424.1
Coordinates 2385965..2386213 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP94_RS11530 (2381181) 2381181..2382647 + 1467 WP_000987828.1 hypothetical protein -
PQP94_RS11535 (2383455) 2383455..2384169 + 715 Protein_2254 helix-turn-helix domain-containing protein -
PQP94_RS11540 (2384225) 2384225..2385133 - 909 WP_010989018.1 hypothetical protein -
PQP94_RS11545 (2385276) 2385276..2385608 - 333 WP_000253154.1 DUF1493 family protein -
PQP94_RS11550 (2385598) 2385598..2385813 - 216 WP_000206207.1 hypothetical protein -
PQP94_RS11555 (2385965) 2385965..2386213 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP94_RS11560 (2386203) 2386203..2386487 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP94_RS11565 (2386658) 2386658..2387047 + 390 WP_000194089.1 RidA family protein -
PQP94_RS11570 (2387099) 2387099..2388178 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP94_RS11575 (2388371) 2388371..2388859 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP94_RS11580 (2388904) 2388904..2390412 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2381184..2393269 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270616 WP_000221343.1 NZ_CP117338:2386203-2386487 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270616 WP_000885424.1 NZ_CP117338:2385965-2386213 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References