Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4652664..4653266 Replicon chromosome
Accession NZ_CP117336
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM052

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag PQP91_RS22790 Protein ID WP_001159635.1
Coordinates 4652955..4653266 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP91_RS22785 Protein ID WP_000362050.1
Coordinates 4652664..4652954 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP91_RS22770 (4650157) 4650157..4651059 + 903 WP_000331367.1 formate dehydrogenase subunit beta -
PQP91_RS22775 (4651056) 4651056..4651691 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP91_RS22780 (4651688) 4651688..4652617 + 930 WP_000027737.1 formate dehydrogenase accessory protein FdhE -
PQP91_RS22785 (4652664) 4652664..4652954 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP91_RS22790 (4652955) 4652955..4653266 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP91_RS22795 (4653484) 4653484..4654413 + 930 WP_001127708.1 alpha/beta hydrolase -
PQP91_RS22800 (4654499) 4654499..4654810 + 312 WP_000558169.1 type II toxin-antitoxin system HigB family toxin -
PQP91_RS22805 (4654807) 4654807..4655253 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
PQP91_RS22810 (4655268) 4655268..4656209 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP91_RS22815 (4656254) 4656254..4656691 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP91_RS22820 (4656688) 4656688..4657560 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP91_RS22825 (4657554) 4657554..4658153 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T270600 WP_001159635.1 NZ_CP117336:c4653266-4652955 [Salmonella enterica subsp. enterica serovar Dublin]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270600 WP_000362050.1 NZ_CP117336:c4652954-4652664 [Salmonella enterica subsp. enterica serovar Dublin]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References