Detailed information of TA system TA270580

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 65356..65609
• Replicon: plasmid pRM055_1
• Accession: NZ_CP117333
• Organism: Salmonella enterica subsp. enterica serovar Muenster strain RM055

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: -
• Locus tag: PQP79_RS23210
• Protein ID: WP_064764570.1
• Coordinates: 65460..65609 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	65356..65410 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PQP79_RS23180 (60504)	60504..61064	+	561	WP_021569950.1	fertility inhibition protein FinO	-
PQP79_RS23185 (61845)	61845..63434	+	1590	WP_244578662.1	YadA C-terminal domain-containing protein	-
PQP79_RS23190 (63436)	63436..63897	+	462	WP_021553165.1	thermonuclease family protein	-
PQP79_RS23195 (63943)	63943..64152	+	210	WP_001333231.1	hemolysin expression modulator Hha	-
PQP79_RS23200 (64190)	64190..64876	+	687	WP_097178542.1	DUF2726 domain-containing protein	-
PQP79_RS23205 (64873)	64873..65181	+	309	WP_096936303.1	hypothetical protein	-
- (65356)	65356..65410	-	55	NuclAT_1	-	Antitoxin
- (65356)	65356..65410	-	55	NuclAT_1	-	Antitoxin
- (65356)	65356..65410	-	55	NuclAT_1	-	Antitoxin
- (65356)	65356..65410	-	55	NuclAT_1	-	Antitoxin
PQP79_RS23210 (65460)	65460..65609	+	150	WP_064764570.1	Hok/Gef family protein	Toxin
PQP79_RS23215 (65893)	65893..66147	+	255	WP_000083830.1	replication regulatory protein RepA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..66452	66452

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5542.67 Da
• Isoelectric Point: 8.7678

>T270580 WP_064764570.1 NZ_CP117333:65460-65609 [Salmonella enterica subsp. enterica serovar Muenster]
MTKYALIGLIAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T270580 NZ_CP117333:65460-65609 [Salmonella enterica subsp. enterica serovar Muenster]
ATGACGAAATATGCCCTTATCGGGTTGATCGCTGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT270580 NZ_CP117333:c65410-65356 [Salmonella enterica subsp. enterica serovar Muenster]
ACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Antitoxin