Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4505208..4505810 Replicon chromosome
Accession NZ_CP117332
Organism Salmonella enterica subsp. enterica serovar Muenster strain RM055

Toxin (Protein)


Gene name higB Uniprot ID V7IUJ1
Locus tag PQP79_RS21835 Protein ID WP_001159632.1
Coordinates 4505499..4505810 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP79_RS21830 Protein ID WP_000362050.1
Coordinates 4505208..4505498 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP79_RS21815 (4502701) 4502701..4503603 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQP79_RS21820 (4503600) 4503600..4504235 + 636 WP_274881231.1 formate dehydrogenase cytochrome b556 subunit -
PQP79_RS21825 (4504232) 4504232..4505161 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP79_RS21830 (4505208) 4505208..4505498 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP79_RS21835 (4505499) 4505499..4505810 - 312 WP_001159632.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP79_RS21840 (4506028) 4506028..4506957 + 930 WP_001609281.1 alpha/beta hydrolase -
PQP79_RS21845 (4507043) 4507043..4507354 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQP79_RS21850 (4507351) 4507351..4507797 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP79_RS21855 (4507812) 4507812..4508753 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP79_RS21860 (4508798) 4508798..4509235 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP79_RS21865 (4509232) 4509232..4510104 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQP79_RS21870 (4510098) 4510098..4510697 - 600 WP_001646959.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12342.27 Da        Isoelectric Point: 9.4460

>T270575 WP_001159632.1 NZ_CP117332:c4505810-4505499 [Salmonella enterica subsp. enterica serovar Muenster]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270575 WP_000362050.1 NZ_CP117332:c4505498-4505208 [Salmonella enterica subsp. enterica serovar Muenster]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U7VQ31

Antitoxin

Source ID Structure

References