Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4537371..4537973 | Replicon | chromosome |
Accession | NZ_CP117327 | ||
Organism | Salmonella enterica subsp. enterica serovar Saintpaul strain RM106 |
Toxin (Protein)
Gene name | higB | Uniprot ID | C0Q3J8 |
Locus tag | PQP95_RS21795 | Protein ID | WP_001159630.1 |
Coordinates | 4537662..4537973 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | PQP95_RS21790 | Protein ID | WP_000362050.1 |
Coordinates | 4537371..4537661 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PQP95_RS21775 (4534864) | 4534864..4535766 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
PQP95_RS21780 (4535763) | 4535763..4536398 | + | 636 | WP_274891226.1 | formate dehydrogenase cytochrome b556 subunit | - |
PQP95_RS21785 (4536395) | 4536395..4537324 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
PQP95_RS21790 (4537371) | 4537371..4537661 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | Antitoxin |
PQP95_RS21795 (4537662) | 4537662..4537973 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | Toxin |
PQP95_RS21800 (4538191) | 4538191..4539120 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
PQP95_RS21805 (4539206) | 4539206..4539517 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | - |
PQP95_RS21810 (4539514) | 4539514..4539960 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | - |
PQP95_RS21815 (4539975) | 4539975..4540916 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
PQP95_RS21820 (4540961) | 4540961..4541398 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
PQP95_RS21825 (4541395) | 4541395..4542267 | - | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
PQP95_RS21830 (4542261) | 4542261..4542860 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12326.27 Da Isoelectric Point: 9.4460
>T270538 WP_001159630.1 NZ_CP117327:c4537973-4537662 [Salmonella enterica subsp. enterica serovar Saintpaul]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
Download Length: 312 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10971.59 Da Isoelectric Point: 10.6525
>AT270538 WP_000362050.1 NZ_CP117327:c4537661-4537371 [Salmonella enterica subsp. enterica serovar Saintpaul]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|