Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4537371..4537973 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQP95_RS21795 Protein ID WP_001159630.1
Coordinates 4537662..4537973 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP95_RS21790 Protein ID WP_000362050.1
Coordinates 4537371..4537661 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS21775 (4534864) 4534864..4535766 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQP95_RS21780 (4535763) 4535763..4536398 + 636 WP_274891226.1 formate dehydrogenase cytochrome b556 subunit -
PQP95_RS21785 (4536395) 4536395..4537324 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP95_RS21790 (4537371) 4537371..4537661 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP95_RS21795 (4537662) 4537662..4537973 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQP95_RS21800 (4538191) 4538191..4539120 + 930 WP_001127703.1 alpha/beta hydrolase -
PQP95_RS21805 (4539206) 4539206..4539517 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQP95_RS21810 (4539514) 4539514..4539960 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP95_RS21815 (4539975) 4539975..4540916 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP95_RS21820 (4540961) 4540961..4541398 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
PQP95_RS21825 (4541395) 4541395..4542267 - 873 WP_000921427.1 virulence factor BrkB family protein -
PQP95_RS21830 (4542261) 4542261..4542860 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270538 WP_001159630.1 NZ_CP117327:c4537973-4537662 [Salmonella enterica subsp. enterica serovar Saintpaul]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270538 WP_000362050.1 NZ_CP117327:c4537661-4537371 [Salmonella enterica subsp. enterica serovar Saintpaul]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References