Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2329375..2329897 Replicon chromosome
Accession NZ_CP117327
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain RM106

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag PQP95_RS11205 Protein ID WP_000221343.1
Coordinates 2329613..2329897 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQP95_RS11200 Protein ID WP_000885424.1
Coordinates 2329375..2329623 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP95_RS11180 (2325271) 2325271..2326737 + 1467 WP_000987828.1 hypothetical protein -
PQP95_RS11185 (2327545) 2327545..2328259 + 715 Protein_2184 helix-turn-helix domain-containing protein -
PQP95_RS11190 (2328315) 2328315..2328974 - 660 Protein_2185 hypothetical protein -
PQP95_RS11195 (2329008) 2329008..2329223 - 216 WP_000206207.1 hypothetical protein -
PQP95_RS11200 (2329375) 2329375..2329623 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQP95_RS11205 (2329613) 2329613..2329897 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP95_RS11210 (2330068) 2330068..2330457 + 390 WP_000194089.1 RidA family protein -
PQP95_RS11215 (2330509) 2330509..2331588 - 1080 WP_000954691.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQP95_RS11220 (2331781) 2331781..2332269 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
PQP95_RS11225 (2332314) 2332314..2333822 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2325274..2336679 11405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T270531 WP_000221343.1 NZ_CP117327:2329613-2329897 [Salmonella enterica subsp. enterica serovar Saintpaul]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270531 WP_000885424.1 NZ_CP117327:2329375-2329623 [Salmonella enterica subsp. enterica serovar Saintpaul]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References