Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4583490..4584092 Replicon chromosome
Accession NZ_CP117326
Organism Salmonella enterica subsp. enterica serovar Newport strain RM108

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag PQQ05_RS22235 Protein ID WP_001159630.1
Coordinates 4583781..4584092 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQQ05_RS22230 Protein ID WP_000362050.1
Coordinates 4583490..4583780 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ05_RS22215 (4580983) 4580983..4581885 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
PQQ05_RS22220 (4581882) 4581882..4582517 + 636 WP_274891226.1 formate dehydrogenase cytochrome b556 subunit -
PQQ05_RS22225 (4582514) 4582514..4583443 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQQ05_RS22230 (4583490) 4583490..4583780 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQQ05_RS22235 (4583781) 4583781..4584092 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
PQQ05_RS22240 (4584310) 4584310..4585239 + 930 WP_001127704.1 alpha/beta hydrolase -
PQQ05_RS22245 (4585325) 4585325..4585636 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
PQQ05_RS22250 (4585633) 4585633..4586079 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQQ05_RS22255 (4586094) 4586094..4587035 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQQ05_RS22260 (4587080) 4587080..4587517 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQQ05_RS22265 (4587514) 4587514..4588386 - 873 WP_000921423.1 virulence factor BrkB family protein -
PQQ05_RS22270 (4588380) 4588380..4588979 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T270519 WP_001159630.1 NZ_CP117326:c4584092-4583781 [Salmonella enterica subsp. enterica serovar Newport]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270519 WP_000362050.1 NZ_CP117326:c4583780-4583490 [Salmonella enterica subsp. enterica serovar Newport]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References