Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4650827..4651429 Replicon chromosome
Accession NZ_CP117322
Organism Salmonella enterica subsp. enterica serovar Derby strain RM001

Toxin (Protein)


Gene name higB Uniprot ID A0A3Y7R225
Locus tag PQP82_RS22615 Protein ID WP_023232499.1
Coordinates 4651118..4651429 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PQP82_RS22610 Protein ID WP_000362050.1
Coordinates 4650827..4651117 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP82_RS22595 (4648320) 4648320..4649222 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
PQP82_RS22600 (4649219) 4649219..4649854 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
PQP82_RS22605 (4649851) 4649851..4650780 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
PQP82_RS22610 (4650827) 4650827..4651117 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
PQP82_RS22615 (4651118) 4651118..4651429 - 312 WP_023232499.1 hypothetical protein Toxin
PQP82_RS22620 (4651647) 4651647..4652576 + 930 WP_023232500.1 alpha/beta hydrolase -
PQP82_RS22625 (4652662) 4652662..4652973 + 312 WP_000558164.1 type II toxin-antitoxin system HigB family toxin -
PQP82_RS22630 (4652970) 4652970..4653416 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
PQP82_RS22635 (4653431) 4653431..4654372 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
PQP82_RS22640 (4654417) 4654417..4654854 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
PQP82_RS22645 (4654851) 4654851..4655720 - 870 WP_023203606.1 virulence factor BrkB family protein -
PQP82_RS22650 (4655714) 4655714..4656313 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12388.34 Da        Isoelectric Point: 9.4460

>T270504 WP_023232499.1 NZ_CP117322:c4651429-4651118 [Salmonella enterica subsp. enterica serovar Derby]
MQFIETELFTEDVKKLLDDDEYHKFQVFMAQHPDCGDVIQETGGLRKMRWGVRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT270504 WP_000362050.1 NZ_CP117322:c4651117-4650827 [Salmonella enterica subsp. enterica serovar Derby]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y7R225

Antitoxin

Source ID Structure

References