Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4633675..4634429 | Replicon | chromosome |
Accession | NZ_CP117317 | ||
Organism | Salmonella enterica subsp. enterica serovar Derby strain RM002 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | PQQ14_RS22510 | Protein ID | WP_274881348.1 |
Coordinates | 4633675..4633986 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | PQQ14_RS22515 | Protein ID | WP_001259011.1 |
Coordinates | 4633983..4634429 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PQQ14_RS22480 (4629333) | 4629333..4630235 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
PQQ14_RS22485 (4630232) | 4630232..4630867 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
PQQ14_RS22490 (4630864) | 4630864..4631793 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
PQQ14_RS22495 (4631840) | 4631840..4632130 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
PQQ14_RS22500 (4632131) | 4632131..4632442 | - | 312 | WP_023232499.1 | hypothetical protein | - |
PQQ14_RS22505 (4632660) | 4632660..4633589 | + | 930 | WP_023232500.1 | alpha/beta hydrolase | - |
PQQ14_RS22510 (4633675) | 4633675..4633986 | + | 312 | WP_274881348.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
PQQ14_RS22515 (4633983) | 4633983..4634429 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
PQQ14_RS22520 (4634444) | 4634444..4635385 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
PQQ14_RS22525 (4635430) | 4635430..4635867 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
PQQ14_RS22530 (4635864) | 4635864..4636733 | - | 870 | WP_023203606.1 | virulence factor BrkB family protein | - |
PQQ14_RS22535 (4636727) | 4636727..4637326 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
PQQ14_RS22540 (4637517) | 4637517..4638320 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
PQQ14_RS22545 (4638354) | 4638354..4639250 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T270484 WP_274881348.1 NZ_CP117317:4633675-4633986 [Salmonella enterica subsp. enterica serovar Derby]
VHVISRKPFNEAMLMYPNHELALTELLNVLERKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLKLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLERKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLKLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT270484 WP_001259011.1 NZ_CP117317:4633983-4634429 [Salmonella enterica subsp. enterica serovar Derby]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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