Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 351218..351756 Replicon chromosome
Accession NZ_CP117317
Organism Salmonella enterica subsp. enterica serovar Derby strain RM002

Toxin (Protein)


Gene name yafQ Uniprot ID A0A3V8R2L4
Locus tag PQQ14_RS01570 Protein ID WP_023231798.1
Coordinates 351481..351756 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A7U1KUN1
Locus tag PQQ14_RS01565 Protein ID WP_000729714.1
Coordinates 351218..351478 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ14_RS01550 (346971) 346971..348524 + 1554 WP_023231801.1 TROVE domain-containing protein -
PQQ14_RS01555 (348872) 348872..350086 + 1215 WP_052895236.1 RNA-splicing ligase RtcB -
PQQ14_RS01560 (350090) 350090..351109 + 1020 WP_023231799.1 RNA 3'-terminal phosphate cyclase -
PQQ14_RS01565 (351218) 351218..351478 + 261 WP_000729714.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ14_RS01570 (351481) 351481..351756 + 276 WP_023231798.1 type II toxin-antitoxin system YafQ family toxin Toxin
PQQ14_RS01575 (351844) 351844..354549 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10645.22 Da        Isoelectric Point: 8.8623

>T270469 WP_023231798.1 NZ_CP117317:351481-351756 [Salmonella enterica subsp. enterica serovar Derby]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDYPLQGSYSGYRDAHIGPDWILIDKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9445.82 Da        Isoelectric Point: 4.6028

>AT270469 WP_000729714.1 NZ_CP117317:351218-351478 [Salmonella enterica subsp. enterica serovar Derby]
MAANALVRARIDETLKNQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8R2L4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U1KUN1

References